Etiket: royal jelly

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ARI SÜTÜ VE KANSER

ARI SÜTÜ KANSER HASTALARINA FAYDA SAĞLAR MI?

İleri evre böbrek kanserinde akıllı ilaç(hedefe yönelik moleküler tedavi) kullanılırken arı sütü verilen hastalarda tedavi daha etkin; yan etkiler daha az görülmüştür. Arı sütünün faydalı olduğu tespit edilmiştir. Ancak daha fazla sayıda hasta üzerinde çalışmalara ihtiyaç vardır. Dr. Dursun Ünal

Miyata, Y., et al. (2020). “Oral intake of royal jelly improves anti-cancer effects and suppresses adverse events of molecular targeted therapy by regulating TNF-alpha and TGF-beta in renal cell carcinoma: A preliminary study based on a randomized double-blind clinical trial.” Molecular and Clinical Oncology 13(4).

Molecular targeted therapies are commonly used in patients with metastatic renal cell carcinoma (RCC). However, the efficacy and safety of these therapeutic interventions require enhancement to improve prognosis in these patients. Royal jelly (RJ) has anti-cancer effects and adverse events across a variety of types of malignancy. The present study investigated the detailed mechanism underlying the effects of oral administration of RJ in patients with advanced RCC that were treated with molecular targeted agents in a randomized clinical trial. The study cohort comprised 16 patients treated with RJ and 17 patients treated with a placebo. Serum levels of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta were measured using enzyme-linked immunosorbent assays. The results of the present study demonstrated a larger decrease in tumor size upon supplementing patients with RJ following molecular targeted therapy compared with that in patients administered with the placebo. Patients exhibited reduced anorexia and fatigue in the RJ group compared with the placebo group. The relative dose intensity for patients in the RJ group was higher than that in patients in the placebo group. Post- and pre-treatment ratios of the serum levels of TNF-alpha and TGF-beta in patients in the RJ group were lower than those in patients in the placebo group, and these ratios correlated with decreasing tumor size and frequency of anorexia or fatigue in patients. In conclusion, the results of the present study indicated that oral intake of RJ improved the efficacy and safety of molecular targeted therapy in patients with RCC and changed the levels of TNF-alpha and TGF-beta in the serum of patients, which is speculated to serve an important role in RJ-induced biological activities.

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ARI SÜTÜ VE EPİGENETİK

ARI SÜTÜNÜN EPİGENETİK ÖZELLİĞİ VAR MIDIR?

Arı sütü epigenetik kavramını bize özetler. Epigenetik gen ifadesi veya hücresel fenotipte DNA dizisinden bağımsız olan mekanizmaların neden olduğu farklılaşmalardır. İşçi arılar 2n kromozoma sahiptir. Yani kraliçe arıyla aynı genetik yapıya sahiptir. Kraliçe arıya larva dönemi ve hayatı boyunca verilen arı sütü bu farklılaşmayı sağlamıştır. İşçi arı ortalama 45 gün yaşayabilir. Kraliçe arı 7 yıla kadar yaşayabilir. Ana arı bir günde kendi ağırlığının 2 katı yumurta bırakabilir. İşçi arıyla ana arının genetik yapıları aynı fakat birbirinden çok farklı vücut yapıları, üretim kapasiteleri ve ömürleri vardır. Paylaştığım makale bu durumu belirtmektedir.

Alhosin, M. (2023). “Epigenetics Mechanisms of Honeybees: Secrets of Royal Jelly.” Epigenet Insights 16: 25168657231213717.

Early diets in honeybees have effects on epigenome with consequences on their phenotype. Depending on the early larval diet, either royal jelly (RJ) or royal worker, 2 different female castes are generated from identical genomes, a long-lived queen with fully developed ovaries and a short-lived functionally sterile worker. To generate these prominent physiological and morphological differences between queen and worker, honeybees utilize epigenetic mechanisms which are controlled by nutritional input. These mechanisms include DNA methylation and histone post-translational modifications, mainly histone acetylation. In honeybee larvae, DNA methylation and histone acetylation may be differentially altered by RJ. This diet has biologically active ingredients with inhibitory effects on the de novo methyltransferase DNMT3A or the histone deacetylase 3 HDAC3 to create and maintain the epigenetic state necessary for developing larvae to generate a queen. DNMT and HDAC enzymes work together to induce the formation of a compacted chromatin structure, repressing transcription. Such dialog could be coordinated by their association with other epigenetic factors including the ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) fi nger domains 1 (UHRF1). Through its multiple functional domains, UHRF1 acts as an epigenetic reader of both DNA methylation patterns and histone marks. The present review discusses the epigenetic regulation of honeybee’s chromatin and how the early diets in honeybees can affect the DNA/histone modifying types of machinery that are necessary to stimulate the larvae to turn into either queen or worker. The review also looks at future directions in epigenetics mechanisms of honeybees, mainly the potential role of UHRF1 in these mechanisms.